Antidepressants and Rem Sleep Behavior Disorder

1579 Antidepressants and REM Sleep Behavior Disorder—Postuma et al INTRODUCTION REM sleep behavior disorder (RBD) is a parasomnia characterized by loss of the normal atonia of REM sleep, such that patients appear to act out their dreams.1 Behaviors include yelling, laughing or crying, complex voluntary movements, falling out of bed, and even violent behaviors with injury. RBD is not rare—the prevalence of severe and violent RBD is approximately 1/2002; milder forms may increase this estimate considerably. Most patients with RBD do not seek medical attention, and lack of awareness among physicians can exacerbate this under-recognition.1 RBD has received considerable recent attention because it is strongly associated with synuclein-mediated neurodegenerative diseases such as Parkinson disease (PD), dementia with Lewy Bodies (DLB), and multiple system atrophy. Of special interest, RBD can predict these ANTIDEPRESSANTS AND REM SLEEP BEHAVIOR DISORDER